Nonsense-mediated mRNA decay in mammals.

نویسنده

  • Lynne E Maquat
چکیده

Nonsense-mediated mRNA decay (NMD) in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exonexon junction (reviewed in Maquat, 2004a; Nagy and Maquat, 1998). Notably, dependence on exon-exon junctions distinguishes NMD in mammalian cells from NMD in all other organisms that have been examined, including Saccharomyces cerevisiae and Drosophila melanogaster (reviewed in Maquat, 2004b). NMD downregulates spliced mRNAs that prematurely terminate translation so

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عنوان ژورنال:
  • Journal of cell science

دوره 118 Pt 9  شماره 

صفحات  -

تاریخ انتشار 2005